Structure of PDB 3mj5 Chain B

Receptor sequence
>3mj5B (length=262) [Search protein sequence]
TFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTS
IKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILA
YSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVE
AVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKL
QQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDV
FYKETSYTTTIK
3D structure
PDB3mj5 Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: design, synthesis, protein-ligand X-ray structure and biological evaluation
ChainB
Resolution2.63 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.50: mRNA guanylyltransferase.
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GRM B M209 G210 Y269 M155 G156 Y215 BindingDB: IC50=320nM
BS02 GRM B G164 D165 P249 Y265 Y269 Q270 Y274 T302 G110 D111 P195 Y211 Y215 Q216 Y220 T248 BindingDB: IC50=320nM
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3mj5, PDBe:3mj5, PDBj:3mj5
PDBsum3mj5
PubMed20527968
UniProtP0C6U8|R1A_SARS Replicase polyprotein 1a (Gene Name=1a)

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