Structure of PDB 3miy Chain B

Receptor sequence
>3miyB (length=240) Species: 9606 (Homo sapiens) [Search protein sequence]
GSVIDPSELTFVQEIGSGGLVHLGYWLNKDKVAIKTISEEDFIEEAEVMM
KLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLG
MCLDVCEGMAYLEEASVIHRDLAARNCLVGENQVIKVSDFGPVKWASPEV
FSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYK
PRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAAIAASG
3D structure
PDB3miy Crystal structures of IL-2-inducible T cell kinase complexed with inhibitors: insights into rational drug design and activity regulation.
ChainB
Resolution1.67 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D482 A484 R486 N487 D500 P521
Catalytic site (residue number reindexed from 1) D121 A123 R125 N126 D139 P142
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B49 B I369 A389 K391 F435 M438 E439 G441 L489 I15 A33 K35 F74 M77 E78 G80 L128 MOAD: Kd=21nM
BindingDB: Kd=13nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3miy, PDBe:3miy, PDBj:3miy
PDBsum3miy
PubMed20545945
UniProtQ08881|ITK_HUMAN Tyrosine-protein kinase ITK/TSK (Gene Name=ITK)

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