Structure of PDB 3mbc Chain B

Receptor sequence

>3mbcB (length=735) Species: 196627 (Corynebacterium glutamicum ATCC 13032)

AKIIWTRTDEAPLLATYSLKPVVEAFAATAGIEVETRDISLAGRILAQFP
ERLTEDQKVGNALAELGELAKTPEANIIKLPNISASVPQLKAAIKELQDQ
GYDIPELPDNATTDEEKDILARYNAVKGSAVNPVLREGNSDRRAPIAVKN
FVKKFPHRMGEWSADSKTNVATMDANDFRHNEKSIILDAADEVQIKHIAA
DGTETILKDSLKLLEGEVLDGTVLSAKALDAFLLEQVARAKAEGILFSAH
LKATMMKVSDPIIFGHVVRAYFADVFAQYGEQLLAAGLNGENGLAAILSG
LESLDNGEEIKAAFEKGLEDGPDLAMVNSARGITNLHVPSDVIVDASMPA
MIRTSGHMWNKDDQEQDTLAIIPDSSYAGVYQTVIEDCRKNGAFDPTTMG
TVPNVGLMAQKAEEYGSHDKTFRIEADGVVQVVSSNGDVLIEHDVEANDI
WRACQVKDAPIQDWVKLAVTRSRLSGMPAVFWLDPERAHDRNLASLVEKY
LADHDTEGLDIQILSPVEATQLSIDRIRRGEDTISVTGNVLRDYNTDLFP
ILELGTSAKMLSVVPLMAGGGLFETGAGGSAPKHVQQVQEENHLRWDSLG
EFLALAESFRHELNNNGNTKAGVLADALDKATEKLLNEEKSPSRKVGEID
NRGSHFWLTKFWADELAAQTEDADLAATFAPVAEALNTGAADIDAALLAV
QGGATDLGGYYSPNEEKLTNIMRPVAQFNEIVDAL

3D structure

• PDB: 3mbc Structure of a highly NADP+-specific isocitrate dehydrogenase.
• Chain: B
• Resolution: 1.9 Å

Enzymatic activity

• Enzyme Commision number: 1.1.1.42: isocitrate dehydrogenase (NADP(+)).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	B	D346 D544 D548	D345 D543 D547

Gene Ontology

Molecular Function

• GO:0004450 isocitrate dehydrogenase (NADP+) activity
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006097 glyoxylate cycle
• GO:0006099 tricarboxylic acid cycle

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:3mbc, PDBe:3mbc, PDBj:3mbc
• PDBsum: 3mbc
• PubMed: 21931217
• UniProt: P50216|IDH_CORGL Isocitrate dehydrogenase [NADP] (Gene Name=icd)