Structure of PDB 3mb8 Chain B

Receptor sequence
>3mb8B (length=248) Species: 5811 (Toxoplasma gondii) [Search protein sequence]
LMQGMEVQPHIRLRKEDVEPVVIIVGDPARTEEVANMCEKKQELAYNREY
RSFRVVYDSQPITVISHGIGCPGTSIAIEELAYLGAKVIIRAGTCGSLKP
KTLKQGDVCVTYAAVNETGLISNILPEGFPCVATPHVYQALMDAAKELGI
EAASGIGVTQDYFYQNGILPSKLEMYSKCCDVIDMEMSGVLGLCQARGIA
TCGILAVDGSPLQWDEGDYDATGVKATTGKENMVKITLKACANLRRQY
3D structure
PDB3mb8 Inhibition and Structure of Toxoplasma gondii Purine Nucleoside Phosphorylase.
ChainB
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H12 G28 R32 R50 E82 R93 T96 D210 G211 P213 V226
Catalytic site (residue number reindexed from 1) H10 G26 R30 R48 E80 R91 T94 D208 G209 P211 V224
Enzyme Commision number 2.4.2.1: purine-nucleoside phosphorylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IMH B T96 C97 G98 F165 D186 M187 E188 D210 T94 C95 G96 F163 D184 M185 E186 D208
BS02 PO4 B G28 R32 R93 T96 G26 R30 R91 T94
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004731 purine-nucleoside phosphorylase activity
GO:0004850 uridine phosphorylase activity
GO:0016757 glycosyltransferase activity
Biological Process
GO:0006218 uridine catabolic process
GO:0009116 nucleoside metabolic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3mb8, PDBe:3mb8, PDBj:3mb8
PDBsum3mb8
PubMed24585883
UniProtQ2HXR2

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