Structure of PDB 3m9e Chain B

Receptor sequence
>3m9eB (length=99) Species: 10116 (Rattus norvegicus) [Search protein sequence]
ELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKSLHPSYSCKYEGKCIID
KVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREE
3D structure
PDB3m9e Structure of a thyroid hormone receptor DNA-binding domain homodimer bound to an inverted palindrome DNA response element.
ChainB
Resolution2.406 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B E124 G125 F129 R132 R157 N158 Q161 R164 I191 N194 R195 E21 G22 F26 R29 R54 N55 Q58 R61 I88 N91 R92 PDBbind-CN: Kd=0.13uM
BS02 dna B H117 Y118 K127 R131 L177 V178 L179 R184 K187 R188 H14 Y15 K24 R28 L74 V75 L76 R81 K84 R85 PDBbind-CN: Kd=0.13uM
BS03 ZN B C106 C109 C123 C126 C3 C6 C20 C23
BS04 ZN B C144 C150 C160 C163 C41 C47 C57 C60
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:3m9e, PDBe:3m9e, PDBj:3m9e
PDBsum3m9e
PubMed20610536
UniProtP18113|THB_RAT Thyroid hormone receptor beta (Gene Name=Thrb)

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