Structure of PDB 3lug Chain B

Receptor sequence
>3lugB (length=134) Species: 9606 (Homo sapiens) [Search protein sequence]
NKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQ
PCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDT
VLGMATQCVQMKNVQRTTPQTLSNLCLKINVKLG
3D structure
PDB3lug Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2.
ChainB
Resolution1.849 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.26.n2: argonaute-2.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C5P B Y529 K533 Q545 C546 K570 Y91 K95 Q107 C108 K132 MOAD: Kd=3.6mM
BS02 PO4 B R475 R479 R37 R41
BS03 PO4 B K493 H507 Y512 K55 H69 Y74
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding

View graph for
Molecular Function
External links
PDB RCSB:3lug, PDBe:3lug, PDBj:3lug
PDBsum3lug
PubMed20505670
UniProtQ9UKV8|AGO2_HUMAN Protein argonaute-2 (Gene Name=AGO2)

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