Structure of PDB 3lud Chain B

Receptor sequence
>3ludB (length=132) Species: 9606 (Homo sapiens) [Search protein sequence]
KQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQP
CFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTV
LGMATQCVQMKNVQRTTPQTLSNLCLKINVKL
3D structure
PDB3lud Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2.
ChainB
Resolution2.095 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.26.n2: argonaute-2.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP B G524 T526 Y529 K533 Q545 C546 Q548 K570 G85 T87 Y90 K94 Q106 C107 Q109 K131 MOAD: Kd=0.26mM
BS02 PO4 B R475 R479 R36 R40
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding

View graph for
Molecular Function
External links
PDB RCSB:3lud, PDBe:3lud, PDBj:3lud
PDBsum3lud
PubMed20505670
UniProtQ9UKV8|AGO2_HUMAN Protein argonaute-2 (Gene Name=AGO2)

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