Structure of PDB 3lmy Chain B

Receptor sequence
>3lmyB (length=480) Species: 9606 (Homo sapiens) [Search protein sequence]
PALWPLPLSVKMTPNLLHLAPENFYISHSPNSTAGPSCTLLEEAFRRYHG
YIFGTQVQQLLVSITLQSECDAFPNISSDESYTLLVKEPVAVLKANRVWG
ALRGLETFSQLVYQDSYGTFTINESTIIDSPRFSHRGILIDTSRHYLPVK
IILKTLDAMAFNKFNVLHWHIVDDQSFPYQSITFPELSNKGSYSLSHVYT
PNDVRMVIEYARLRGIRVLPEFDTPGHTLSWGKGQKDLLTPCYSDSFGPI
NPTLNTTYSFLTTFFKEISEVFPDQFIHLGGDEVEFKCWESNPKIQDFMR
QKGFGTDFKKLESFYIQKVLDIIATINKGSIVWQEVFDDKAKLAPGTIVE
VWKDSAYPEELSRVTASGFPVILSAPWYLDLISYGQDWRKYYKVEPLDFG
GTQKQKQLFIGGEACLWGEYVDATNLTPRLWPRASAVGERLWSSKDVRDM
DDAYDRLTRHRCRMVERGIAAQPLYAGYCN
3D structure
PDB3lmy The Crystal Structure of beta-hexosaminidase B in complex with Pyrimethamine
ChainB
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D354 E355
Catalytic site (residue number reindexed from 1) D282 E283
Enzyme Commision number 3.2.1.52: beta-N-acetylhexosaminidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CP6 B R211 H237 H294 D354 E355 W424 Y450 W489 E491 R144 H170 H227 D282 E283 W352 Y378 W417 E419 BindingDB: IC50=9100nM
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004563 beta-N-acetylhexosaminidase activity
Biological Process
GO:0005975 carbohydrate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3lmy, PDBe:3lmy, PDBj:3lmy
PDBsum3lmy
PubMed
UniProtP07686|HEXB_HUMAN Beta-hexosaminidase subunit beta (Gene Name=HEXB)

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