Structure of PDB 3lgz Chain B

Receptor sequence
>3lgzB (length=279) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
MTMMDMNFKYCHKIMKKHSKSFSYAFDLLPEDQRKAVWAIYAVCRKIDDS
IIQFLNQIKEDIQSIEKYPYEYHHFQSDRRIMMALQHVAQHKNIAFQSFY
NLIDTVYKDQHFTMFETDAELFGACYGVAGTVGEVLTPILSDHETHQTYD
VARRLGESLQLINILRDVGEDFENERIYFSKQRLKQYEVDIAEVYQNGVN
NHYIDLWEYYAAIAEKDFRDVMDQIKVFSIEAQPIIELAARIYIEILDEV
RQANYTLHERVFVEKRKKAKLFHEINSKY
3D structure
PDB3lgz Mechanism of action and inhibition of dehydrosqualene synthase.
ChainB
Resolution2.41 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.96: 4,4'-diapophytoene synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PS7 B H18 Y41 C44 R45 D48 V137 L160 L164 Q165 R171 Y248 H18 Y41 C44 R45 D48 V132 L155 L159 Q160 R166 Y243
BS02 MG B N168 D172 N163 D167
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0016740 transferase activity
GO:0016767 geranylgeranyl-diphosphate geranylgeranyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0009058 biosynthetic process
GO:0016117 carotenoid biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3lgz, PDBe:3lgz, PDBj:3lgz
PDBsum3lgz
PubMed21098670
UniProtA9JQL9|CRTM_STAAU 4,4'-diapophytoene synthase (Gene Name=crtM)

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