Structure of PDB 3lgn Chain B

Receptor sequence

>3lgnB (length=109) Species: 158879 (Staphylococcus aureus subsp. aureus N315)

HMFMAENRLQLQKGSAEETIERFYNRQGIETIEGFQQMFVTKTLNTEDTD
EVKILTIWESEDSFNNWLNSDVFKEAHKNVRLKSDDDGQQSPILSNKVFK
YDIGYHYQK

3D structure

• PDB: 3lgn The IsdG-family of haem oxygenases degrades haem to a novel chromophore
• Chain: B
• Resolution: 1.5 Å

Enzymatic activity

• Enzyme Commision number: 1.14.99.48: heme oxygenase (staphylobilin-producing).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	HEM	B	N6 R21 F22 R25 Q26 I28 I53 W66 H76 V79 N95	N7 R22 F23 R26 Q27 I29 I54 W67 H77 V80 N96
BS02	OXY	B	N6 F22 I53	N7 F23 I54

Gene Ontology

Molecular Function

• GO:0004392 heme oxygenase (decyclizing) activity
• GO:0004497 monooxygenase activity
• GO:0005506 iron ion binding
• GO:0020037 heme binding
• GO:0046872 metal ion binding

Biological Process

• GO:0033212 iron import into cell
• GO:0042167 heme catabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:3lgn, PDBe:3lgn, PDBj:3lgn
• PDBsum: 3lgn
• PubMed: 20180905
• UniProt: Q7A827|HDOX2_STAAN Heme oxygenase (staphylobilin-producing) 2 (Gene Name=isdI)