Structure of PDB 3lgg Chain B

Receptor sequence
>3lggB (length=482) Species: 9606 (Homo sapiens) [Search protein sequence]
SIDETRAHLLLKEKMMRLGGRLVLNTKEELANERLMTLKIAEMKEAMRTL
IFPPSMHFFQAKHLIERSQVFNILRMMPKGAALHLHDIGIVTMDWLVRNV
TYRPHCHICFTPRGIMQFRFAHPTPRPSEKCSKWILLEDYRKRVQNVTEF
DDSLLRNFTLVTQHPEVIYTNQNVVWSKFETIFFTISGLIHYAPVFRDYV
FRSMQEFYEDNVLYMEIRARLLPVYELSGEHHDEEWSVKTYQEVAQKFVE
THPEFIGIKIIYSDHRSKDVAVIAESIRMAMGLRIKFPTVVAGFDLVGHE
DTGHSLHDYKEALMIPAKDGVKLPYFFHAGETDWQGTSIDRNILDALMLN
TTRIGHGFALSKHPAVRTYSWKKDIPIEVCPISNQVLKLVSDLRNHPVAT
LMATGHPMVISSDDPAMFGAKGLSYDFYEVFMGIGGMKADLRTLKQLAMN
SIKYSTLLESEKNTFMEIWKKRWDKFIADVAT
3D structure
PDB3lgg Structural basis for the growth factor activity of human adenosine deaminase ADA2.
ChainB
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.4.4: adenosine deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H86 H88 H330 D415 H84 H86 H328 D413
BS02 CFE B H88 D89 W178 F181 E182 F185 H267 V299 G300 H330 E333 D415 D416 H86 D87 W176 F179 E180 F183 H265 V297 G298 H328 E331 D413 D414
Gene Ontology
Molecular Function
GO:0004000 adenosine deaminase activity
GO:0019239 deaminase activity
Biological Process
GO:0006154 adenosine catabolic process
Cellular Component
GO:0005615 extracellular space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3lgg, PDBe:3lgg, PDBj:3lgg
PDBsum3lgg
PubMed20147294
UniProtQ9NZK5|ADA2_HUMAN Adenosine deaminase 2 (Gene Name=ADA2)

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