Structure of PDB 3lcv Chain B

Receptor sequence
>3lcvB (length=259) Species: 1879 (Micromonospora zionensis) [Search protein sequence]
DRIDEIERAITKSRRYQTVAPATVRRLARAALVAARGDVPDAVKRTKRGL
HEIYGAFLPPSPPNYAALLRHLDSAVDAGDDEAVRAALLRAMSVHISTRE
RLPHLDEFYRELFRHLPRPNTLRDLACGLNPLAAPWMGLPAETVYIASDI
DARLVGFVDEALTRLNVPHRTNVADLLEDRLDEPADVTLLLKTLPCLETQ
QRGSGWEVIDIVNSPNIVVTFPTKGMFQNYSQSFESQARERSCRIQRLEI
GNELIYVIQ
3D structure
PDB3lcv Structural basis for the methylation of G1405 in 16S rRNA by aminoglycoside resistance methyltransferase Sgm from an antibiotic producer: a diversity of active sites in m7G methyltransferases.
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.179: 16S rRNA (guanine(1405)-N(7))-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM B I60 F64 S104 T105 R108 A133 C134 D156 I157 D182 L183 L198 K199 Q207 I53 F57 S97 T98 R101 A126 C127 D149 I150 D175 L176 L191 K192 Q200 MOAD: Kd=18uM
PDBbind-CN: -logKd/Ki=4.74,Kd=18uM
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008649 rRNA methyltransferase activity
Biological Process
GO:0006364 rRNA processing
GO:0031167 rRNA methylation
GO:0032259 methylation
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:3lcv, PDBe:3lcv, PDBj:3lcv
PDBsum3lcv
PubMed20194115
UniProtQ7M0R2|SGM_MICZI 16S rRNA (guanine(1405)-N(7))-methyltransferase (Gene Name=sgm)

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