Structure of PDB 3lcb Chain B

Receptor sequence

>3lcbB (length=561) Species: 83334 (Escherichia coli O157:H7) [Search protein sequence]

LELLIAQTILQGFDAQYGRFLEVTSGAQQRFEQADWHAVQQAMKNRIHLY
DHHVGLVVEQLRCITNEFLLRVKEHYTRLLPDYPRFEIAESFFNSVYCRL
FDHRSLTPERLFIFSSQPERRFRTIPRPLAKDFHPDHGWESLLMRVISDL
PLRLHWQNKSRDIHYIIRHLTETLGPENLSKSHLQVANELFYRNKAAWLV
GKLITPSGTLPFLLPIHQTDDGELFIDTCLTTTAEASIVFGFARSYFMVY
APLPAALVEWLREILPGKTTAELYMAIGCQKHAKTESYREYLVYLQGCNE
QFIEAPGIRGMVMLVFTLPGFDRVFKVIKDKFAPQKEMSAAHVRACYQLV
KEHDRVGRMADTQEFENFVLEKRHISPALMELLLQEAAEKITDLGEQIVI
RHLYIERRMVPLNIWLEQVEGQQLRDAIEEYGNAIRQLAAANIFPGDMLF
KNFGVTRHGRVVFYDYDEICYMTEVNFRDIPPPRYPEDELASEPWYSVSP
GDVFPEEFRHWLCADPRIGPLFEEMHADLFRADYWRALQNRIREGHVEDV
YAYRRRQRFSV

3D structure

PDB

3lcb Structure of the bifunctional isocitrate dehydrogenase kinase/phosphatase.

Chain

Resolution

2.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.11.5: [isocitrate dehydrogenase (NADP(+))] kinase.
3.1.3.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ATP	B	I318 G320 M321 V322 M323 V325 V334 K336 K346 E416 M419 D457 K461 N462 Y474 D475 D477	I308 G310 M311 V312 M313 V315 V324 K326 K336 E406 M409 D447 K451 N452 Y464 D465 D467
BS02	AMP	B	N104 S105 H113 L116 K291 K294 T295 Y298 F375 N377	N94 S95 H103 L106 K281 K284 T285 Y288 F365 N367
BS03	MG	B	N462 D475	N452 D465

Gene Ontology

	Molecular Function
GO:0004674	protein serine/threonine kinase activity
GO:0004721	phosphoprotein phosphatase activity
GO:0005524	ATP binding
GO:0008772	[isocitrate dehydrogenase (NADP+)] kinase activity
GO:0016208	AMP binding
GO:0016788	hydrolase activity, acting on ester bonds
GO:0016791	phosphatase activity

	Biological Process
GO:0006006	glucose metabolic process
GO:0006097	glyoxylate cycle
GO:0006099	tricarboxylic acid cycle
GO:0006470	protein dephosphorylation
GO:0016310	phosphorylation
GO:0018105	peptidyl-serine phosphorylation
GO:0050790	regulation of catalytic activity

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:3lcb, PDBe:3lcb, PDBj:3lcb
PDBsum	3lcb
PubMed	20505668
UniProt	Q8X607\|ACEK_ECO57 Isocitrate dehydrogenase kinase/phosphatase (Gene Name=aceK)

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