Structure of PDB 3lc6 Chain B

Receptor sequence
>3lc6B (length=539) Species: 83334 (Escherichia coli O157:H7) [Search protein sequence]
PRGLELLIAQTILQGFDAQYGRFLEVTSGAQQRFEQADWHAVQQAMKNRI
HLYDHHVGLVVEQLRCITNGQSTDAEFLLRVKEHYTRLLPDYPRFEIAES
FFNSVYCRLDHRSLTPERLFIFSSQPTIPRPLAKDFHPDHGWESLLMRVI
SDLPLRLHWQNKSRDIHYIIRHLTETLGPENLSKSHLQVANELFYRNKAA
WLVGKLITPSGTLPFLLPIHQTDDGELFIDTCLTTTAEASIVFGFARSYF
MVYAPLPAALVEWLREILPGKTTAELYMAIGCQKHAKTESYREYLVYLQG
CNEQFIEAPGIRGMVMLVFTLPGFDRVFKVIKDKFAHVRACYQLVKEHDR
VGRMADTQEFENFVLEKRHISPALMELLLQEAAEKITDLGEQIVIRHLYI
ERRMVPLNIWLEQVEGQQLRDAIEEYGNAIRQLAAANIFPGDMLFKNFGV
TRHGRVVFYDYDEICYMTEVNFRDIGDVFPEEFRHWLCADPRIGPLFEEM
HADLFRADYWRALQNRIREGHVEDVYAYRRRQRFSVRYG
3D structure
PDB3lc6 Structure of the bifunctional isocitrate dehydrogenase kinase/phosphatase.
ChainB
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.5: [isocitrate dehydrogenase (NADP(+))] kinase.
3.1.3.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP B S101 N104 S105 H113 I123 K291 K294 F375 N377 S100 N103 S104 H111 I121 K284 K287 F360 N362
Gene Ontology
Molecular Function
GO:0004674 protein serine/threonine kinase activity
GO:0004721 phosphoprotein phosphatase activity
GO:0005524 ATP binding
GO:0008772 [isocitrate dehydrogenase (NADP+)] kinase activity
GO:0016208 AMP binding
GO:0016788 hydrolase activity, acting on ester bonds
GO:0016791 phosphatase activity
Biological Process
GO:0006006 glucose metabolic process
GO:0006097 glyoxylate cycle
GO:0006099 tricarboxylic acid cycle
GO:0006470 protein dephosphorylation
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3lc6, PDBe:3lc6, PDBj:3lc6
PDBsum3lc6
PubMed20505668
UniProtQ8X607|ACEK_ECO57 Isocitrate dehydrogenase kinase/phosphatase (Gene Name=aceK)

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