Structure of PDB 3l9x Chain B

Receptor sequence
>3l9xB (length=336) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
MRVIIAGFGRFGQITGRLLLSSGVKMVVLDHDPDHIETLRKFGMKVFYGD
ATRMDLLESAGAAKAEVLINAIDDPQTNLQLTEMVKEHFPHLQIIARARD
VDHYIRLRQAGVEKPERETFEGALKTGRLALESLGLGPYEARERADVFRR
FNIQMVEEMAMVMILIIYAHPYPHHSHANKRMLEQARTLEGVEIRSLYQL
YPDFNIDIAAEQEALSRADLIVWQHPMQWYSIPPLLKLWIDKVFSHGWAY
GHGGTALHGKHLLWAVTTGGGESHFEIGAHPGFDVLSQPLQATAIYCGLN
WLPPFAMHCTFICDDETLEGQARHYKQRLLEWQEAH
3D structure
PDB3l9x Mechanism of ligand-gated potassium efflux in bacterial pathogens.
ChainB
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G1107 F1113 H1118
Catalytic site (residue number reindexed from 1) G269 F275 H280
Enzyme Commision number ?
1.6.5.2: NAD(P)H dehydrogenase (quinone).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ESG B R498 D499 V500 R516 R99 D100 V101 R117
BS02 ZN B Y1010 H1012 Y172 H174
BS03 FMN B H1008 S1014 H1015 A1016 N1017 P1064 M1065 Q1066 W1067 Y1068 T1105 G1107 H1112 T1148 H170 S176 H177 A178 N179 P226 M227 Q228 W229 Y230 T267 G269 H274 T310
BS04 L9X B R498 D499 V500 R516 R99 D100 V101 R117
Gene Ontology
Molecular Function
GO:0003955 NAD(P)H dehydrogenase (quinone) activity
GO:0005515 protein binding
GO:0008753 NADPH dehydrogenase (quinone) activity
GO:0009055 electron transfer activity
GO:0010181 FMN binding
GO:0015079 potassium ion transmembrane transporter activity
GO:0016491 oxidoreductase activity
GO:0042803 protein homodimerization activity
GO:0050136 NADH:ubiquinone reductase (non-electrogenic) activity
Biological Process
GO:0006813 potassium ion transport
GO:0032414 positive regulation of ion transmembrane transporter activity
GO:0051453 regulation of intracellular pH
GO:0051454 intracellular pH elevation
GO:1901381 positive regulation of potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:1903103 potassium:proton antiporter complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3l9x, PDBe:3l9x, PDBj:3l9x
PDBsum3l9x
PubMed21041667
UniProtP03819|KEFC_ECOLI Glutathione-regulated potassium-efflux system protein KefC (Gene Name=kefC);
P0A754

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