Structure of PDB 3l6c Chain B

Receptor sequence
>3l6cB (length=312) Species: 10116 (Rattus norvegicus) [Search protein sequence]
QYDISFADVEKAHLNIQDSVHLTPVLTSSILNQIAGRNLFFKCELFQKTG
SFKIRGALNAIRGPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPN
CKKLAIQAYGASIVYSEPSDESRENVAQRIIQETEGILVHPNQEPAVIAG
QGTIALEVLNQVPLVDALVVPVGGGGMVAGIAITIKTLKPSVKVYAAEPS
NADDCYQSKLKGELTPNLHPPETIADGVKSSIGLNTWPIIRDLVDDVFTV
TEDEIKYATQLVWERMKLLIEPTAGVGLAAVLSQHFQTVSPEVKNICIVL
SGGNVDLTSLSW
3D structure
PDB3l6c The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding.
ChainB
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K56 S84 E210 A214 D216 G239 T285 L312 S313
Catalytic site (residue number reindexed from 1) K53 S72 E198 A202 D204 G227 T273 L300 S301
Enzyme Commision number 4.3.1.17: L-serine ammonia-lyase.
4.3.1.18: D-serine ammonia-lyase.
5.1.1.18: serine racemase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP B F55 K56 N86 V184 G185 G186 G187 G188 M189 E283 T285 S313 F52 K53 N74 V172 G173 G174 G175 G176 M177 E271 T273 S301
BS02 MN B E210 A214 D216 E198 A202 D204
BS03 MLI B K56 S83 S84 H87 R135 K53 S71 S72 H75 R123
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0003941 L-serine ammonia-lyase activity
GO:0005509 calcium ion binding
GO:0005524 ATP binding
GO:0008721 D-serine ammonia-lyase activity
GO:0016594 glycine binding
GO:0016829 lyase activity
GO:0016853 isomerase activity
GO:0018114 threonine racemase activity
GO:0030165 PDZ domain binding
GO:0030170 pyridoxal phosphate binding
GO:0030378 serine racemase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006520 amino acid metabolic process
GO:0006563 L-serine metabolic process
GO:0009069 serine family amino acid metabolic process
GO:0009410 response to xenobiotic stimulus
GO:0014070 response to organic cyclic compound
GO:0032496 response to lipopolysaccharide
GO:0042866 pyruvate biosynthetic process
GO:0070178 D-serine metabolic process
GO:0070179 D-serine biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0043025 neuronal cell body
GO:0045177 apical part of cell

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3l6c, PDBe:3l6c, PDBj:3l6c
PDBsum3l6c
PubMed20106978
UniProtQ76EQ0|SRR_RAT Serine racemase (Gene Name=Srr)

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