Structure of PDB 3l4d Chain B

Receptor sequence
>3l4dB (length=449) Species: 5671 (Leishmania infantum) [Search protein sequence]
KGKLPPVVHGTTPFVGHIIQFGKDPLGFMLKAKKKYGGIFTMNICGNRIT
VVGDVHQHSKFFTPRNEILSPREVYSFMVPVFGEGVAYAAPYPRMREQLN
FLAEELTVAKFQNFAPSIQHEVRKFMKANWNKDEGEINILDDCSAMIINT
ACQCLFGEDLRKRLDARQFAQLLAKMESCLIPAAVFLPWILKLPLPQSYR
CRDARAELQDILSEIIIAREKEEAQKDTNTSDLLAGLLGAVYRDGTRMSQ
HEVCGMIVAAMFAGQHTSTITTTWSLLHLMDPRNKRHLAKLHQEIDEFPA
QLNYDNVMEEMPFAEQCARESIRRDPPLVMLMRKVLKPVQVGKYVVPEGD
IIACSPLLSHQDEEAFPNPREWNPERNMKLVDGAFCGFGAGVHKCIGEKF
GLLQVKTVLATVLRDYDFELLGPLPEPNYHTMVVGPTASQCRVKYIKKK
3D structure
PDB3l4d Substrate Preferences and Catalytic Parameters Determined by Structural Characteristics of Sterol 14{alpha}-Demethylase (CYP51) from Leishmania infantum.
ChainB
Resolution2.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) L355 C422
Catalytic site (residue number reindexed from 1) L328 C395
Enzyme Commision number 1.14.13.70: Transferred entry: 1.14.14.154.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM B Y102 Y115 L126 L133 A287 A290 T294 L358 R360 G414 F415 G416 H420 C422 I423 G424 G428 Y75 Y88 L99 L106 A260 A263 T267 L331 R333 G387 F388 G389 H393 C395 I396 G397 G401
BS02 TPF B Y115 A286 F289 A290 L355 M459 Y88 A259 F262 A263 L328 M432
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:3l4d, PDBe:3l4d, PDBj:3l4d
PDBsum3l4d
PubMed21632531
UniProtA2TEF2

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