Structure of PDB 3l0v Chain B

Receptor sequence
>3l0vB (length=252) Species: 9606 (Homo sapiens) [Search protein sequence]
PMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTAWDN
AGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLE
QFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYGGRANSHGGVCPKAYYS
PVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLA
ECAPNEDQGGKYVMYPIAVSGDHENNKMFSQCSKQSIYKTIESKAQECFQ
ER
3D structure
PDB3l0v Discovery and SAR of hydantoin TACE inhibitors.
ChainB
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.86: ADAM 17 endopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H405 H409 H415 H184 H188 H194
BS02 724 B T347 L348 G349 L401 V402 H405 E406 H409 H415 P437 A439 T128 L129 G130 L180 V181 H184 E185 H188 H194 P216 A218 MOAD: Ki=23nM
BindingDB: Ki=23nM
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3l0v, PDBe:3l0v, PDBj:3l0v
PDBsum3l0v
PubMed20172725
UniProtP78536|ADA17_HUMAN Disintegrin and metalloproteinase domain-containing protein 17 (Gene Name=ADAM17)

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