Structure of PDB 3l0k Chain B

Receptor sequence
>3l0kB (length=256) Species: 9606 (Homo sapiens) [Search protein sequence]
ELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADAL
GPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTVK
KQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSS
TGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEA
GGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEA
YLSRLG
3D structure
PDB3l0k Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase
ChainB
Resolution1.34 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.10: orotate phosphoribosyltransferase.
4.1.1.23: orotidine-5'-phosphate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6AU B D93 I94 T97 D94 I95 T98 MOAD: ic50=24uM
PDBbind-CN: -logKd/Ki=4.62,IC50=24uM
BS02 6AU B S33 D35 K57 H59 D88 K90 M147 S148 P193 Q206 Y208 G226 R227 S34 D36 K58 H60 D89 K91 M148 S149 P194 Q207 Y209 G227 R228 MOAD: ic50=24uM
PDBbind-CN: -logKd/Ki=4.62,IC50=24uM
Gene Ontology
Molecular Function
GO:0004590 orotidine-5'-phosphate decarboxylase activity
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0044205 'de novo' UMP biosynthetic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3l0k, PDBe:3l0k, PDBj:3l0k
PDBsum3l0k
PubMed19472232
UniProtP11172|UMPS_HUMAN Uridine 5'-monophosphate synthase (Gene Name=UMPS)

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