Structure of PDB 3kz0 Chain B

Receptor sequence
>3kz0B (length=145) Species: 9606 (Homo sapiens) [Search protein sequence]
DELYRQSLEIISRYLREQATGAKDRSGATSRKALETLRRVGDGVQRNHET
AFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAK
HLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV
3D structure
PDB3kz0 Determinants of BH3 binding specificity for Mcl-1 versus Bcl-xL.
ChainB
Resolution2.349 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B H224 M231 K234 R248 V249 H252 V253 D256 N260 G262 R263 T266 L267 F318 F319 H48 M55 K58 R72 V73 H76 V77 D80 N84 G86 R87 T90 L91 F142 F143
BS02 ZN B E240 D241 E64 D65
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:3kz0, PDBe:3kz0, PDBj:3kz0
PDBsum3kz0
PubMed20363230
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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