Structure of PDB 3ks9 Chain B

Receptor sequence
>3ks9B (length=442) Species: 9606 (Homo sapiens) [Search protein sequence]
QRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFH
TLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLKPIAGVI
GPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTL
QARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLSIAHSDK
IYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVG
EFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLD
TNTRNPWFPEFWQHRFQCRLPNFKRICTGNESLEENYVQDSKMGFVINAI
YAMAHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEV
WFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDD
3D structure
PDB3ks9 Metabotropic glutamate receptor mglur1 complexed with LY341495 antagonist
ChainB
Resolution1.9 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Z99 B Y74 W110 S164 S165 S186 A187 T188 Y236 D318 G319 Y40 W76 S104 S105 S126 A127 T128 Y176 D258 G259 BindingDB: IC50=7800nM,Ki=6800nM
BS02 MG B I89 N90 D92 L95 L96 I55 N56 D58 L61 L62
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3ks9, PDBe:3ks9, PDBj:3ks9
PDBsum3ks9
PubMed
UniProtQ13255|GRM1_HUMAN Metabotropic glutamate receptor 1 (Gene Name=GRM1)

[Back to BioLiP]