Structure of PDB 3kqh Chain B

Receptor sequence
>3kqhB (length=436) Species: 333284 (Hepatitis C virus (isolate Con1)) [Search protein sequence]
SPPAVPQTFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGF
GAYMSKAHGIDPNIRTGVRTITTGAPITYSTYGKFLADGGCSGGAYDIII
CDECHSTDSTTILGIGTVLDQAETAGARLVVLATATPPGSVTVPHPNIEE
VALSSTGEIPFYGKAIPIETIKGGRHLIFCHSKKKCDELAAKLSGLGLNA
VAYYRGLDVSVIPTSGDVIVVATDALMTGFTGDFDSVIDCNTCVTQTVDF
SLDPTFTIETTTVPQDAVSRSQRRGRTGRGRMGIYRFVTPGERPSGMFDS
SVLCECYDAGCAWYELTPAETSVRLRAYLNTPGLPVCQDHLEFWESVFTG
LTHIDAHFLSQTKQAGDNFPYLVAYQATVCARAQAPPPSWDQMWKCLIRL
KPTLHGPTPLLYRLGAVQNEVTTTHPITKYIMACMS
3D structure
PDB3kqh Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism.
ChainB
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B P230 V232 T254 G255 T269 G271 H369 K371 Y392 R393 T411 A413 L414 V432 Q434 T448 T449 T450 W501 Y502 N556 P42 V44 T66 G67 T81 G83 H181 K183 Y204 R205 T223 A225 L226 V244 Q246 T260 T261 T262 W313 Y314 N368
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:3kqh, PDBe:3kqh, PDBj:3kqh
PDBsum3kqh
PubMed20080715
UniProtQ9WMX2|POLG_HCVCO Genome polyprotein

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