Structure of PDB 3kmz Chain B

Receptor sequence
>3kmzB (length=221) Species: 9606 (Homo sapiens) [Search protein sequence]
TPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSE
LSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPE
QDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLS
AICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMK
ITDLRSISAKGAERVITLKME
3D structure
PDB3kmz A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor.
ChainB
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I236 I237 V240 L261 K262 G391 A392 R394 V395 I396 T397 L398 M400 I56 I57 V60 L81 K82 G211 A212 R214 V215 I216 T217 L218 M220
BS02 peptide B N212 V218 D221 N32 V38 D41
BS03 EQO B F228 L231 S232 C235 L269 I270 F286 S287 F302 F48 L51 S52 C55 L89 I90 F106 S107 F122 BindingDB: IC50=114nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0048384 retinoic acid receptor signaling pathway
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3kmz, PDBe:3kmz, PDBj:3kmz
PDBsum3kmz
PubMed20543827
UniProtP10276|RARA_HUMAN Retinoic acid receptor alpha (Gene Name=RARA)

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