Structure of PDB 3klc Chain B

Receptor sequence
>3klcB (length=261) Species: 272844 (Pyrococcus abyssi GE5) [Search protein sequence]
VKVAYVQMNPQILEPDKNYSKAEKLIKEASKQGAQLVVLPELFDTGYNFE
TREEVFEIAQKIPEGETTTFLMDVARDTGVYIVAGTAEKDGDVLYNSAVV
VGPRGFIGKYRKIHLFYREKFFFEPGDLGFRVFDLGFMKVGVMICFDWFF
PESARTLALKGADVIAHPANLVMPYAPRAMPIRALENKVYTVTADRVGEE
RGLKFIGKSLIASPKAEVLSMASETEEEVGVAEIDLSLVRNKRINDLNDI
FKDRREEYYFR
3D structure
PDB3klc Crystallographic analysis of a thermoactive nitrilase.
ChainB
Resolution1.76 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E42 N97 K113 E120 C146 N171
Catalytic site (residue number reindexed from 1) E41 N96 K112 E119 C145 N170
Enzyme Commision number 3.5.5.1: nitrilase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BR B E153 F261 E152 F260
BS02 BR B F107 K110 F106 K109
BS03 BR B L172 M174 L171 M173
BS04 MG B R255 E257 R254 E256
Gene Ontology
Molecular Function
GO:0000257 nitrilase activity
GO:0016787 hydrolase activity
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0080061 indole-3-acetonitrile nitrilase activity

View graph for
Molecular Function
External links
PDB RCSB:3klc, PDBe:3klc, PDBj:3klc
PDBsum3klc
PubMed21095228
UniProtQ9UYV8|NITR_PYRAB Nitrilase (Gene Name=PYRAB13990)

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