Structure of PDB 3kkt Chain B

Receptor sequence
>3kktB (length=338) Species: 9606 (Homo sapiens) [Search protein sequence]
SRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQER
DLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTP
ALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVL
ENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSL
LADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELY
RQWTDRIMEEFFQQGDKERERGMEISPMCDKVEKSQVGFIDYIVHPLWET
WADLVQPDAQDILDTLEDNRNWYQSMCQGLMEKFQFEL
3D structure
PDB3kkt Crystal structure of human PDE4b with 5-[3-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-yloxy]-4-methoxyp henyl]tetrahydro-2(1H)-pyrimidinone reveals ordering of the C-terminal helix residues 502-509.
ChainB
Resolution2.48 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.53: 3',5'-cyclic-AMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H238 H274 D275 D392 H85 H121 D122 D239
BS02 0CP B Y233 T407 I410 Q443 F446 L502 M503 F506 Y80 T254 I257 Q286 F289 L330 M331 F334
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:3kkt, PDBe:3kkt, PDBj:3kkt
PDBsum3kkt
PubMed
UniProtQ07343|PDE4B_HUMAN 3',5'-cyclic-AMP phosphodiesterase 4B (Gene Name=PDE4B)

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