Structure of PDB 3kjq Chain B

Receptor sequence
>3kjqB (length=90) Species: 9606 (Homo sapiens) [Search protein sequence]
TRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDI
LTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
3D structure
PDB3kjq Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors.
ChainB
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.61: caspase-8.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B94 B S411 Y412 R413 P415 S22 Y23 R24 P26 PDBbind-CN: -logKd/Ki=5.88,Ki=1.32uM
BS02 B94 B E396 F399 T467 E7 F10 T78 PDBbind-CN: -logKd/Ki=5.88,Ki=1.32uM
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3kjq, PDBe:3kjq, PDBj:3kjq
PDBsum3kjq
PubMed20580860
UniProtQ14790|CASP8_HUMAN Caspase-8 (Gene Name=CASP8)

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