Structure of PDB 3kjf Chain B

Receptor sequence
>3kjfB (length=102) Species: 9606 (Homo sapiens) [Search protein sequence]
SGVDDDMACHKIPVDADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQ
YADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYF
YH
3D structure
PDB3kjf Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors.
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.56: caspase-3.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B92 B Y204 S205 W206 R207 N208 S209 W214 Y29 S30 W31 R32 N33 S34 W39 PDBbind-CN: -logKd/Ki=4.87,Ki=13.4uM
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3kjf, PDBe:3kjf, PDBj:3kjf
PDBsum3kjf
PubMed20580860
UniProtP42574|CASP3_HUMAN Caspase-3 (Gene Name=CASP3)

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