Structure of PDB 3khj Chain B

Receptor sequence
>3khjB (length=318) Species: 353152 (Cryptosporidium parvum Iowa II) [Search protein sequence]
TKNIGKGLTFEDILLVPNYSEVLPREVSLETKLTKNVSLKIPLISSAMDT
VTEHLMAVGMARLGGIGIIHKNMDMESQVNEVLKVKNSGGLRVGAAIGVN
EIERAKLLVEAGVDVIVLDSAHGHSLNIIRTLKEIKSKMNIDVIVGNVVT
EEATKELIENGADGIKVGIGPGSICTTRIVAGVGVPQITAIEKCSSVASK
FGIPIIADGGIRYSGDIGKALAVGASSVMIGSILAGTEESPGEKELIGDT
VYKYYRGMGSVGAMKMVPEGIEGRVKYKGEMEGVVYQLVGGLRSCMGYLG
SASIEELWKKSSYVEITT
3D structure
PDB3khj The structural basis of Cryptosporidium -specific IMP dehydrogenase inhibitor selectivity.
ChainB
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.205: IMP dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IMP B S48 M50 G216 S217 I218 C219 D252 G275 S276 G301 M302 G303 E329 S46 M48 G172 S173 I174 C175 D208 G231 S232 G257 M258 G259 E269
BS02 C64 B A165 H166 M302 G303 M308 E329 A121 H122 M258 G259 M264 E269 PDBbind-CN: -logKd/Ki=7.55,IC50=28nM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3khj, PDBe:3khj, PDBj:3khj
PDBsum3khj
PubMed20052976
UniProtQ5CPK7

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