Structure of PDB 3kf2 Chain B

Receptor sequence
>3kf2B (length=181) [Search protein sequence]
APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTATQTFLATCING
VCWTVYHGAGTRTIASPKGPVIQMYTNVDQDLVGWPAPQGSRSLTPCTCG
SSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAGHA
VGLFRAAVCTRGVAKAVDFIPVENLETTMRS
3D structure
PDB3kf2 Induced-Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target
ChainB
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.98: hepacivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B T4 A5 Y6 A7 T4 A5 Y6 A7
BS02 peptide B T4 A5 Y6 A7 Q8 T10 R11 C16 S20 E30 E32 V33 I35 V36 S37 R62 T63 I64 A65 T4 A5 Y6 A7 Q8 T10 R11 C16 S20 E30 E32 V33 I35 V36 S37 R62 T63 I64 A65
BS03 ZN B C97 C99 C145 C97 C99 C145
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:3kf2, PDBe:3kf2, PDBj:3kf2
PDBsum3kf2
PubMed20166108
UniProtB2Y2M9

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