Structure of PDB 3kex Chain B

Receptor sequence
>3kexB (length=283) Species: 9606 (Homo sapiens) [Search protein sequence]
KVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDK
SGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLD
HVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQ
VQVADFGVADLLPPDDKQTPIKWMALESIHFGKYTHQSDVWSYGVTVWEL
MTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENI
RPTFKELANEFTRMARDPPRYLVIKREGPGIAP
3D structure
PDB3kex Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3.
ChainB
Resolution2.797 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N815 A817 R819 N820 D833 D843 T854
Catalytic site (residue number reindexed from 1) N137 A139 R141 N142 D155 D165 T169
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP B L696 G697 S698 G699 V700 V704 C721 Y770 L771 N815 R819 N820 L822 D833 L18 G19 S20 G21 V22 V26 C43 Y92 L93 N137 R141 N142 L144 D155
BS02 MG B N820 D833 N142 D155
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3kex, PDBe:3kex, PDBj:3kex
PDBsum3kex
PubMed20007378
UniProtP21860|ERBB3_HUMAN Receptor tyrosine-protein kinase erbB-3 (Gene Name=ERBB3)

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