Structure of PDB 3kdt Chain B

Receptor sequence
>3kdtB (length=271) Species: 9606 (Homo sapiens) [Search protein sequence]
SHMEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKANNPPFVIHD
METLCMAEKTLVVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPG
FANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKS
LRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGH
IEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQI
IKKTESDAALHPLLQEIYRDM
3D structure
PDB3kdt Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453).
ChainB
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7HA B C275 C276 S280 Y314 I317 M330 V332 M355 H440 C79 C80 S84 Y118 I121 M134 V136 M159 H244 BindingDB: EC50=10nM,IC50=260nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3kdt, PDBe:3kdt, PDBj:3kdt
PDBsum3kdt
PubMed20218621
UniProtQ07869|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

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