Structure of PDB 3kcz Chain B

Receptor sequence
>3kczB (length=348) Species: 9606 (Homo sapiens) [Search protein sequence]
TENLYFQSMDLRVQELIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQI
KAGYQSLKKIEDCIRAGQHGRALMEACNEFYTRIPHDFGLRTPPLIRTQK
ELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQHYRNLHCALRPLDHE
SYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDLHNRML
LWHGSRMSNWVGILSHGLRIAHPEAPITGYMFGKGIYFADMSSKSANYCF
ASRLKNTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSS
AHFVTLNGSTVPLGPASDTGYTLNYNEYIVYNPNQVRMRYLLKVQFNF
3D structure
PDB3kcz Crystal structure of the catalytic domain of human PARP2 in complex with PARP inhibitor ABT-888.
ChainB
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K264 A265 I289 F305 T307 S470 Y473 E558
Catalytic site (residue number reindexed from 1) K39 A40 I64 F80 T82 S245 Y248 E327
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3AB B H428 G429 F463 S470 Y473 H203 G204 F238 S245 Y248
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:3kcz, PDBe:3kcz, PDBj:3kcz
PDBsum3kcz
PubMed20092359
UniProtQ9UGN5|PARP2_HUMAN Poly [ADP-ribose] polymerase 2 (Gene Name=PARP2)

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