Structure of PDB 3kba Chain B

Receptor sequence
>3kbaB (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
QLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVK
WSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPD
LILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIP
LEGLRSQTQFEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLH
DLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFH
3D structure
PDB3kba Improving the developability profile of pyrrolidine progesterone receptor partial agonists.
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WOW B L718 N719 L721 G722 M759 F778 F794 M801 L887 Y890 C891 T894 F905 L37 N38 L40 G41 M78 F97 F113 M120 L206 Y209 C210 T213 F224 MOAD: ic50=16nM
BindingDB: IC50=16nM,EC50=25nM
External links
PDB RCSB:3kba, PDBe:3kba, PDBj:3kba
PDBsum3kba
PubMed19926282
UniProtP06401|PRGR_HUMAN Progesterone receptor (Gene Name=PGR)

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