Structure of PDB 3k3b Chain B

Receptor sequence
>3k3bB (length=331) Species: 9606 (Homo sapiens) [Search protein sequence]
GKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTDKSSRKTYTFD
MVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGER
SPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELF
DLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAA
KRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGS
ENGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSII
ATISPASLNLEETLSTLEYAHRAKNILNKPE
3D structure
PDB3k3b The discovery of tetrahydro-beta-carbolines as inhibitors of the kinesin Eg5.
ChainB
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B R24 R26 P27 G108 T109 G110 K111 T112 F113 E118 R9 R11 P12 G89 T90 G91 K92 T93 F94 E99
BS02 L31 B E116 E118 R119 W127 D130 A133 I136 P137 Y211 L214 E97 E99 R100 W108 D111 A114 I117 P118 Y192 L195 MOAD: ic50=0.2uM
BindingDB: IC50=200nM
Gene Ontology
Molecular Function
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement

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Molecular Function
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Biological Process
External links
PDB RCSB:3k3b, PDBe:3k3b, PDBj:3k3b
PDBsum3k3b
PubMed19945875
UniProtP52732|KIF11_HUMAN Kinesin-like protein KIF11 (Gene Name=KIF11)

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