Structure of PDB 3k23 Chain B

Receptor sequence
>3k23B (length=247) Species: 9606 (Homo sapiens) [Search protein sequence]
QLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVK
WAKAIPGFRNLHLDDQMTLLQYSWMYLMAFALGWRSYRQSSANLLCFAPD
LIINEQRMTLPGMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVP
KDGLKSQELFDEIRMTYIKELGKAIVKRESQNWQRFYQLTKLLDSMHEVV
ENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQ
3D structure
PDB3k23 Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor.
ChainB
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B V575 K579 M593 E751 M752 V49 K53 M67 E222 M223
BS02 JZN B P541 M560 L563 N564 L566 Q570 M604 A607 R611 F623 Q642 M646 L732 Y735 P15 M34 L37 N38 L40 Q44 M78 A81 R85 F97 Q116 M120 L203 Y206 BindingDB: IC50=6.3nM
External links
PDB RCSB:3k23, PDBe:3k23, PDBj:3k23
PDBsum3k23
PubMed19822747
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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