Structure of PDB 3k22 Chain B

Receptor sequence

>3k22B (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]

TLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIA
AVKWAKAIPGFRNLHLDDQMTLLQYSWMYLMAFALGWRSYRQSANLLCFA
PDLIINEQRMTLPGMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSS
VPKDGLKSQELFDEIRMTYIKELGKAIVKRENSQNWQRFYQLTKLLDSMH
EVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQ

3D structure

PDB

3k22 Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor.

Chain

Resolution

2.1 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	B	V575 K579 Q592 M593 M752 E755	V52 K56 Q69 M70 M226 E229
BS02	JZS	B	P541 L563 N564 L566 G567 Q570 W600 M601 M604 A607 L608 F623 C736	P18 L40 N41 L43 G44 Q47 W77 M78 M81 A84 L85 F99 C210
BS03	JZR	B	T556 P637 G638 Q642 Y735 M745	T33 P113 G114 Q118 Y209 M219
BS04	JZR	B	E688 M691 K695	E164 M167 K171

External links

PDB	RCSB:3k22, PDBe:3k22, PDBj:3k22
PDBsum	3k22
PubMed	19822747
UniProt	P04150\|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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