Structure of PDB 3jwr Chain B

Receptor sequence
>3jwrB (length=328) Species: 9606 (Homo sapiens) [Search protein sequence]
SHMEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTD
LNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKA
GKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIM
EHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKR
RGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAEL
VATEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTQLYEA
LTHVSEDCFPLLDGCRKNRQKWQALAEQ
3D structure
PDB3jwr Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the gamma-subunit
ChainB
Resolution2.994 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.35: 3',5'-cyclic-GMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B H678 I802 M804 G819 F820 F823 H147 I271 M273 G288 F289 F292
BS02 ZN B H617 H653 D654 D764 H86 H122 D123 D233
BS03 IBM B F786 F820 F255 F289
BS04 IBM B L701 S702 L704 I706 Y709 L170 S171 L173 I175 Y178
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:3jwr, PDBe:3jwr, PDBj:3jwr
PDBsum3jwr
PubMed19798052
UniProtO76074|PDE5A_HUMAN cGMP-specific 3',5'-cyclic phosphodiesterase (Gene Name=PDE5A);
P51160

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