Structure of PDB 3jb9 Chain B

Receptor sequence
>3jb9B (length=904) Species: 284812 (Schizosaccharomyces pombe 972h-) [Search protein sequence]
AVVLHEDKQYYPSAEEVYGSNVDIMVQEQDTQPLSQPIIEPIRHKRIAIE
TTNVPDTVYKKEFLFGLLTGTDDVRSFIVAGHLHHGKSALLDLLVYYTHP
DTKPPKRRSLRYTDTHYLERERVMSIKSTPLTLAVSDMKGKTFAFQCIDT
PGHVDFVDEVAAPMAISDGVVLVVDVIEGVMINTTRIIKHAILHDMPIVL
VLNKVDRLILELRLPPNDAYHKLRHVIDEVNDNICQISKDLKYRVSPELG
NVCFASCDLGYCFTLSSFAKLYIDRHGGIDVDLFSKRLWGDIYFDSKTRK
FAKQSLDGSGVRSFVHFILEPLYKLHTLTISDEAEKLKKHLSSFQIYLKP
KDYLLDPKPLLQLICASFFGFPVGFVNAVTRHIPSPRENAARKASQSYIG
PINSSIGKAILEMSREESAPLVMHVTKLYNTVDANNFYAFARVYSGQVKK
GQKVKVLGENYSLEDEEDMVVAHIAEICVPCARYRLHVDGAVAGMLVLLG
GVDNSISKTATIVSDNLKDDPYIFRPIAHMSESVFKVAVEPHNPSELPKL
LDGLRKTNKSYPLSITKVEESGEHTIFGTGEMYMDCLLYDLRTLYSEIEI
RVSDPVARFCETAVDTSSIKCFSDTPNKKNRITMVVEPLEKGISNDIENG
KVNINWPQKRISEFFQKNYDWDLLASRSIWAFGPDDRGTNILRDDTLSTD
VDKNVLNSVKEYIKQGFQWGTREGPLCDETIRNVNFRLMDVVLAPEQIYR
GGGQIIPTARRVCYSSFLTASPRLMEPVYMVEVHAPADSLPIIYDLLTRR
RGHVLQDIPRPGSPLYLVRALIPVIDSCGFETDLRVHTQGQAMCQMVFDH
WQVVPGDPLDKSIKPKPLEPARGSDLARDFLIKTRRRKGLVEDVSTTRYF
DQEM
3D structure
PDB3jb9 Structure of a yeast spliceosome at 3.6-angstrom resolution
ChainB
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B I116 E117 T118 T119 Y184 R187 K405 Y414 R550 I49 E50 T51 T52 Y117 R120 K338 Y347 R483
BS02 GDP B G153 K154 S155 S192 K271 D273 S323 D325 G86 K87 S88 S125 K204 D206 S256 D258
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0030623 U5 snRNA binding
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0140727 siRNA-mediated pericentric heterochromatin formation
Cellular Component
GO:0000974 Prp19 complex
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005682 U5 snRNP
GO:0005721 pericentric heterochromatin
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071014 post-mRNA release spliceosomal complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3jb9, PDBe:3jb9, PDBj:3jb9
PDBsum3jb9
PubMed26292707
UniProtO94316|SN114_SCHPO Pre-mRNA-splicing factor cwf10 (Gene Name=cwf10)

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