Structure of PDB 3j0a Chain B

Receptor sequence
>3j0aB (length=632) Species: 9606 (Homo sapiens) [Search protein sequence]
SCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQL
QLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLF
ELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSL
KSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNP
FRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFH
NIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYN
KINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHI
AIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKIN
LTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSEN
PSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVF
SHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLS
VLDITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLF
SLSTEGCFSLFIVCTVTLTLFLMTILTVTKFR
3D structure
PDB3j0a Toll-like receptor 5 forms asymmetric dimers in the absence of flagellin.
ChainB
Resolution26.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FUC B N592 H596 N570 H574
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005149 interleukin-1 receptor binding
GO:0005515 protein binding
GO:0038023 signaling receptor activity
GO:0038187 pattern recognition receptor activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0032757 positive regulation of interleukin-8 production
GO:0034146 toll-like receptor 5 signaling pathway
GO:0045087 innate immune response
GO:0071260 cellular response to mechanical stimulus
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:3j0a, PDBe:3j0a, PDBj:3j0a
PDBsum3j0a
PubMed22173220
UniProtO60602|TLR5_HUMAN Toll-like receptor 5 (Gene Name=TLR5)

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