Structure of PDB 3ivt Chain B

Receptor sequence
>3ivtB (length=400) Species: 4896 (Schizosaccharomyces pombe) [Search protein sequence]
VSEANGTETIKPPMPYGPNPSDFLSRVNNFSIIESTLREGEQFANAFFDT
EKKIQIAKALDNFGVDYIELTSPVASEQSRQDCEAICKLGLKCKILTHIR
CHMDDARVAVETGVDGVDVVIGTSQYLRKYSHGKDMTYIIDSATEVINFV
KSKGIEVRFSSEDSFRSDLVDLLSLYKAVDKIGVNRVGIADTVGCATPRQ
VYDLIRTLRGVVSCDIECHFHNDTGMAIANAYCALEAGATHIDTSILGIG
ERNGITPLGALLARMYVTDREYITHKYKLNQLRELENLVADAVEVQIPFN
NYITGMCAFTHKAGIHAKAILANPSTYEILKPEDFGMSRYVHVGSRLTGW
NAIKSRAEQLNLHLTDAQAKELTVRIKKLADVRTLAMDDVDRVLREYHAD
3D structure
PDB3ivt Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.
ChainB
Resolution2.67 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) Q47
Catalytic site (residue number reindexed from 1) Q42
Enzyme Commision number 2.3.3.14: homocitrate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B E44 H224 H226 E39 H219 H221
BS02 AKG B R43 H103 R163 S165 T197 H224 H226 R38 H98 R158 S160 T192 H219 H221
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004410 homocitrate synthase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
GO:0046912 acyltransferase activity, acyl groups converted into alkyl on transfer
Biological Process
GO:0009085 lysine biosynthetic process
GO:0019752 carboxylic acid metabolic process
GO:0019878 lysine biosynthetic process via aminoadipic acid
GO:0043436 oxoacid metabolic process
GO:0044283 small molecule biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3ivt, PDBe:3ivt, PDBj:3ivt
PDBsum3ivt
PubMed19776021
UniProtQ9Y823|HOSM_SCHPO Homocitrate synthase, mitochondrial (Gene Name=lys4)

[Back to BioLiP]