Structure of PDB 3ipu Chain B

Receptor sequence
>3ipuB (length=235) Species: 9606 (Homo sapiens) [Search protein sequence]
QLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPSREARQQRFAHFTEL
AIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGS
ESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLI
AISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMK
LVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDV
3D structure
PDB3ipu X-ray structures of the LXRalpha LBD in its homodimeric form and implications for heterodimer signaling.
ChainB
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B V269 K273 R283 E284 I287 A288 K291 P437 E441 V59 K63 R73 E74 I77 A78 K81 P227 E231
BS02 O40 B R232 T302 R305 F315 H421 R28 T92 R95 F105 H211 MOAD: Ki=48nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006629 lipid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3ipu, PDBe:3ipu, PDBj:3ipu
PDBsum3ipu
PubMed20382159
UniProtQ13133|NR1H3_HUMAN Oxysterols receptor LXR-alpha (Gene Name=NR1H3)

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