Structure of PDB 3ikf Chain B

Receptor sequence
>3ikfB (length=153) Species: 28450 (Burkholderia pseudomallei) [Search protein sequence]
MDFRIGQGYDVHQLVPGRPLIIGGVTIPYERGLLDADVLLHAITDALFGA
AALGDIGRHFSDTDPRFADSRALLRECASRVAQAGFAIRNVDSTIIAQAP
KLAPHIDAMRANIAADLDLPLDRVNVKAKTNEKLGYLGRGEGIEAQAAAL
VVR
3D structure
PDB3ikf Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei.
ChainB
Resolution2.07 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.6.1.12: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 717 B K134 E137 K129 E132 BindingDB: Kd=135000nM
BS02 ZN B D10 H12 H44 D10 H12 H41
BS03 717 B D10 H12 H44 I59 D10 H12 H41 I56 BindingDB: Kd=135000nM
Gene Ontology
Molecular Function
GO:0008685 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0016114 terpenoid biosynthetic process
GO:0019288 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:3ikf, PDBe:3ikf, PDBj:3ikf
PDBsum3ikf
PubMed21359640
UniProtQ63T71|ISPF_BURPS 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (Gene Name=ispF)

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