Structure of PDB 3ike Chain B

Receptor sequence
>3ikeB (length=153) Species: 28450 (Burkholderia pseudomallei) [Search protein sequence]
MDFRIGQGYDVHQLVPGRPLIIGGVTIPYERGLLDADVLLHAITDALFGA
AALGDIGRHFSDTDPRFADSRALLRECASRVAQAGFAIRNVDSTIIAQAP
KLAPHIDAMRANIAADLDLPLDRVNVKAKTNEKLGYLGRGEGIEAQAAAL
VVR
3D structure
PDB3ike Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei.
ChainB
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.6.1.12: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CYT B A102 P105 K106 L107 A108 K134 T135 A97 P100 K101 L102 A103 K129 T130
BS02 ZN B D10 H12 H44 D10 H12 H41
Gene Ontology
Molecular Function
GO:0008685 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0016114 terpenoid biosynthetic process
GO:0019288 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:3ike, PDBe:3ike, PDBj:3ike
PDBsum3ike
PubMed21359640
UniProtQ63T71|ISPF_BURPS 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (Gene Name=ispF)

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