Structure of PDB 3iiq Chain B

Receptor sequence
>3iiqB (length=224) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
IYEPFQIPSGSMMPTLLIGDFILVEKFTGHPKRGDIVVFKYPEDPKLDYI
KRAVGLPGDKVTYDPVSKELTIQPGCSSGCENALPVTYSNVEPSDFVQTF
SRRNATSGFFEVPKNETKENGIRLSERKETLGDVTHRILTVPIAQDQVGM
YYQQPGQQLATWIVPPGQYFMMGDNRDNSADSRYWGFVPEANLVGRATAI
WMSFDKQEGEWPTGLRLSRIGGIH
3D structure
PDB3iiq Crystallographic Analysis of Bacterial Signal Peptidase in Ternary Complex with Arylomycin A2 and a Beta-Sultam Inhibitor.
ChainB
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S88 S90 K145 S278
Catalytic site (residue number reindexed from 1) S9 S11 K51 S179
Enzyme Commision number 3.4.21.89: signal peptidase I.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B P83 F84 Q85 P87 D142 Y143 I144 P4 F5 Q6 P8 D48 Y49 I50
BS02 JZA B S88 S90 N277 S278 A279 S9 S11 N178 S179 A180 MOAD: ic50=610uM
BS03 TRT B F196 D276 S278 A279 Y283 F100 D177 S179 A180 Y184
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006465 signal peptide processing
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3iiq, PDBe:3iiq, PDBj:3iiq
PDBsum3iiq
PubMed19655811
UniProtP00803|LEP_ECOLI Signal peptidase I (Gene Name=lepB)

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