Structure of PDB 3igz Chain B

Receptor sequence
>3igzB (length=549) Species: 5665 (Leishmania mexicana) [Search protein sequence]
LLLKPHKDLPRRTVLIVVMDGLGIGPEDDYDAVHMASTPFMDAHRRDNRH
FRCVRAHGTAVGLPTDADMGNSEVGHNALGAGRVALQGASLVDDAIKSGE
IYTGEGYRYLHGAFSKEGSTLHLIGLLSDGGVHSRDNQIYSIIEHAVKDG
AKRIRVHALYDGRDVPDGSSFRFTDELEAVLAKVRQNGCDAAIASGGGRM
FVTMDRYDADWSIVERGWRAQVLGDARHFHSAKEAITTFREEDPKVTDQY
YPPFIVVDEQDKPLGTIEDGDAVLCVNFRGDRVIEMTRAFEDEDFNKFDR
VRVPKVRYAGMMRYDGDLGIPNNFLVPPPKLTRVSEEYLCGSGLNIFACS
ETQKFGHVTYFWNGNRSGKIDEKHETFKEVPSDRVQFNEKPRMQSAAITE
AAIEALKSGMYNVVRINFPNGDMVGHTGDLKATITGVEAVDESLAKLKDA
VDSVNGVYIVTADHGNSDDMAQRDKKGKPMKDGNGNVLPLTSHTLSPVPV
FIGGAGLDPRVAMRTDLPAAGLANVTATFINLLGFEAPEDYEPSLIYVE
3D structure
PDB3igz Crystal structures of Leishmania mexicana phosphoglycerate mutase suggest a one-metal mechanism and a new enzyme subclass
ChainB
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D23 R282 K357 D425 H429 D466 H467 H496
Catalytic site (residue number reindexed from 1) D20 R279 K354 D422 H426 D463 H464 H493
Enzyme Commision number 5.4.2.12: phosphoglycerate mutase (2,3-diphosphoglycerate-independent).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CO B D425 H429 H467 H496 D422 H426 H464 H493
BS02 CO B D23 S75 D466 H467 D20 S72 D463 H464
BS03 2PG B S75 H136 D167 R202 R209 R282 R285 K357 D425 H429 H496 S72 H133 D164 R199 R206 R279 R282 K354 D422 H426 H493
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004619 phosphoglycerate mutase activity
GO:0016853 isomerase activity
GO:0030145 manganese ion binding
GO:0046537 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
GO:0046872 metal ion binding
Biological Process
GO:0006007 glucose catabolic process
GO:0006096 glycolytic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3igz, PDBe:3igz, PDBj:3igz
PDBsum3igz
PubMed19781556
UniProtQ86N96

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