Structure of PDB 3iai Chain B

Receptor sequence
>3iaiB (length=252) Species: 9606 (Homo sapiens) [Search protein sequence]
HWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFSPALRPLELLGFQLPP
LPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEH
TVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAY
EQLLSRLEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQG
VIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEAS
FP
3D structure
PDB3iai Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX.
ChainB
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H64 H94 H96 E106 H119 T199
Catalytic site (residue number reindexed from 1) H61 H87 H89 E99 H112 T193
Enzyme Commision number 4.2.1.1: carbonic anhydrase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H94 H96 H119 H87 H89 H112
BS02 AZM B H94 V121 L198 T199 T200 W209 H87 V114 L192 T193 T194 W203 BindingDB: Ki=25nM,IC50=1520nM,Kd=20nM
Gene Ontology
Molecular Function
GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:3iai, PDBe:3iai, PDBj:3iai
PDBsum3iai
PubMed19805286
UniProtQ16790|CAH9_HUMAN Carbonic anhydrase 9 (Gene Name=CA9)

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