BioLiP

>3i8eB (length=1114) Species: 9606 (Homo sapiens) [Search protein sequence]

MSYNYVVTAQKPTAVNGCVTGHFTSAEDLNLLIAKNTRLEIYVVTAEGLR
PVKEVGMYGKIAVMELFRPKGESKDLLFILTAKYNACILEYKQSGESIDI
ITRAHGNVQDRIGRPSETGIIGIIDPECRMIGLRLYDGLFKVIPLDRDNK
ELKAFNIRLEELHVIDVKFLYGCQAPTICFVYQDPQGRHVKTYEVSLREK
EFNKGPWKQENVEAEASMVIAVPEPFGGAIIIGQESITYHNGDKYLAIAP
PIIKQSTIVCHNRVDPNGSRYLLGDMEGRLFMLLLEKEEQMDGTVTLKDL
RVELLGETSIAECLTYLDNGVVFVGSRLGDSQLVKLNVDSNEQGSYVVAM
ETFTNLGPIVDMCVVDLERQGQGQLVTCSGAFKEGSLRIIRNGIGIHEHA
SIDLPGIKGLWPLRSDPNRETYDTLVLSFVGQTRVLMLNGEEVEETELMG
FVDDQQTFFCGNVAHQQLIQITSASVRLVSQEPKALVSEWKEPQAKNISV
ASCNSSQVVVAVGRALYYLQIHPQELRQISHTEMEHEVACLDITPLGDSN
GLSPLCAIGLWTDISARILKLPSFELLHKEMLGGEIIPRSILMTTFESSH
YLLCALGDGALFYFGLNIETGLLSDRKKVTLGTQPTVLRTFRSLSTTNVF
ACSDRPTVIYSSNHKLVFSNVNLKEVNYMCPLNSDGYPDSLALANNSTLT
IGTIDEIQKLHIRTVPLYESPRKICYQEVSQCFGVLSSRIEVQDTSGGTT
ALRPSASTQALSSSVSSSKLFSSGEEVEVHNLLIIDQHTFEVLHAHQFLQ
NEYALSLVSCKLGKDPNTYFIVGTAMVYPEEAEPKQGRIVVFQYSDGKLQ
TVAEKEVKGAVYSMVEFNGKLLASINSTVRLYEWTTEKDVRTECNHYNNI
MALYLKTKGDFILVGDLMRSVLLLAYKPMEGNFEEIARDFNPNWMSAVEI
LDDDNFLGAENAFNLFVCQKDSAATTDEERQHLQEVGLFHLGEFVNVFCH
GSLVMQPTQGSVLFGTVNGMIGLVTSLSESWYNLLLDMQNRLNKVIKSVG
KIEHSFWRSFHTERKTEPATGFIDGDLIESFLDISRPKMQEVVANREATA
DDLIKVVEELTRIH

Site
#

Ligand

Ligand
chain

Binding residues on receptor
(original residue number in PDB)

Binding residues on receptor
(residue number reindexed from 1)

Binding affinity

BS01

peptide

R722 Y812 L814 Y837 P838 A841 Y871 L912 N970 F1003 N1005 V1033

R722 Y803 L805 Y828 P829 A832 Y862 L903 N961 F994 N996 V1017

Molecular Function

nucleic acid binding

DNA binding

damaged DNA binding

protein binding

protein-macromolecule adaptor activity

GO:0044877

protein-containing complex binding

GO:0071987

WD40-repeat domain binding

GO:0097602

cullin family protein binding

GO:0160072

ubiquitin ligase complex scaffold activity

	Biological Process
GO:0006281	DNA repair
GO:0006289	nucleotide-excision repair
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006915	apoptotic process
GO:0006974	DNA damage response
GO:0007056	spindle assembly involved in female meiosis
GO:0010498	proteasomal protein catabolic process
GO:0016055	Wnt signaling pathway
GO:0016567	protein ubiquitination
GO:0019076	viral release from host cell
GO:0034644	cellular response to UV
GO:0035234	ectopic germ cell programmed cell death
GO:0042752	regulation of circadian rhythm
GO:0043066	negative regulation of apoptotic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0044725	epigenetic programming in the zygotic pronuclei
GO:0045070	positive regulation of viral genome replication
GO:0045722	positive regulation of gluconeogenesis
GO:0045732	positive regulation of protein catabolic process
GO:0046726	positive regulation by virus of viral protein levels in host cell
GO:0048511	rhythmic process
GO:0051093	negative regulation of developmental process
GO:0051702	biological process involved in interaction with symbiont
GO:0070914	UV-damage excision repair
GO:1901990	regulation of mitotic cell cycle phase transition
GO:2000242	negative regulation of reproductive process

Biological Process

GO:0006281

DNA repair

GO:0006289

nucleotide-excision repair

GO:0006511

ubiquitin-dependent protein catabolic process

GO:0006915

apoptotic process

GO:0006974

DNA damage response

GO:0007056

spindle assembly involved in female meiosis

GO:0010498

proteasomal protein catabolic process

GO:0016055

Wnt signaling pathway

GO:0016567

protein ubiquitination

GO:0019076

viral release from host cell

GO:0034644

cellular response to UV

GO:0035234

ectopic germ cell programmed cell death

GO:0042752

regulation of circadian rhythm

GO:0043066

negative regulation of apoptotic process

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

GO:0044725

epigenetic programming in the zygotic pronuclei

GO:0045070

positive regulation of viral genome replication

GO:0045722

positive regulation of gluconeogenesis

GO:0045732

positive regulation of protein catabolic process

GO:0046726

positive regulation by virus of viral protein levels in host cell

GO:0048511

rhythmic process

GO:0051093

negative regulation of developmental process

GO:0051702

biological process involved in interaction with symbiont

GO:0070914

UV-damage excision repair

GO:1901990

regulation of mitotic cell cycle phase transition

GO:2000242

negative regulation of reproductive process

	Cellular Component
GO:0000781	chromosome, telomeric region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex
GO:0031465	Cul4B-RING E3 ubiquitin ligase complex
GO:0032991	protein-containing complex
GO:0035861	site of double-strand break
GO:0070062	extracellular exosome
GO:0080008	Cul4-RING E3 ubiquitin ligase complex

Cellular Component

GO:0000781

chromosome, telomeric region

extracellular space

nucleus

nucleoplasm

nucleolus