Structure of PDB 3hzg Chain B

Receptor sequence
>3hzgB (length=243) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
AETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPN
PKTATNAGYLRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSY
SQLSQRYVPEKDSRVVVPPGMEDDADLRHILTEAADAARATYSELLAKLE
AKFADQPNAILRRKQARQAARAVLPNATETRIVVTGNYRAWRHFIAMRAS
EHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTEVATS
3D structure
PDB3hzg Increasing the structural coverage of tuberculosis drug targets.
ChainB
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.148: thymidylate synthase (FAD).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD B R95 H96 R97 H194 R199 R94 H95 R96 H193 R198
BS02 FAD B C43 G68 H69 S71 H98 N188 R190 C42 G67 H68 S70 H97 N187 R189
BS03 FAD B Q103 Y108 Q102 Y107
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050797 thymidylate synthase (FAD) activity
GO:0070402 NADPH binding
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3hzg, PDBe:3hzg, PDBj:3hzg
PDBsum3hzg
PubMed25613812
UniProtP9WG57|THYX_MYCTU Flavin-dependent thymidylate synthase (Gene Name=thyX)

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