Structure of PDB 3hyg Chain B

Receptor sequence
>3hygB (length=217) Species: 9606 (Homo sapiens) [Search protein sequence]
SRARQVELLLVADASMARKYGRGLQHYLLTLASIANRLYSHASIENHIRL
AVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAI
LFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIG
HLLGLSHDDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEF
LDDGHGNCLLDLPRKQI
3D structure
PDB3hyg Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors
ChainB
Resolution1.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H410 H414 H420 H147 H151 H157
BS02 CA B E270 D353 D360 C471 D474 E7 D90 D97 C208 D211
BS03 CA B E270 D353 D474 E7 D90 D211
BS04 CA B D369 L370 C376 T378 E398 D106 L107 C113 T115 E135
BS05 099 B D377 T378 L379 T407 H410 E411 H414 H420 S440 S441 I442 L443 D114 T115 L116 T144 H147 E148 H151 H157 S177 S178 I179 L180 MOAD: ic50=93nM
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3hyg, PDBe:3hyg, PDBj:3hyg
PDBsum3hyg
PubMed19586907
UniProtQ9UNA0|ATS5_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 5 (Gene Name=ADAMTS5)

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