Structure of PDB 3hxc Chain B

Receptor sequence
>3hxcB (length=323) Species: 10116 (Rattus norvegicus) [Search protein sequence]
QKDVTIKSDAPDTLLLEKHADYIASYGSYEYCMSEYLRMSGVYWGLTVMD
LMGQLHRMNKEEILVFIKSCQHECGGVSASIGHDPHLLYTLSAVQILTLY
DSIHVINVDKVVAYVQSLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGK
LDAINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLH
QVNSDLLGWWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGRLHWI
DREKLRSFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSLLGEEQIKP
VSPVFCMPEEVLQRVNVQPELVS
3D structure
PDB3hxc Design, synthesis, and characterization of Peptide-based rab geranylgeranyl transferase inhibitors
ChainB
Resolution1.95 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H190 R232 K235 D238 C240 Y241 D280 D287 H290
Catalytic site (residue number reindexed from 1) H182 R224 K227 D230 C232 Y233 D272 D279 H282
Enzyme Commision number 2.5.1.60: protein geranylgeranyltransferase type II.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B D238 C240 H290 D230 C232 H282
BS02 CA B H64 M66 H56 M58
BS03 BD6 B W52 R144 F147 G192 Q193 D238 C240 W244 F289 W44 R136 F139 G184 Q185 D230 C232 W236 F281 PDBbind-CN: -logKd/Ki=5.28,IC50=5.2uM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004659 prenyltransferase activity
GO:0004661 protein geranylgeranyltransferase activity
GO:0004663 Rab geranylgeranyltransferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0008318 protein prenyltransferase activity
GO:0019840 isoprenoid binding
GO:0031267 small GTPase binding
GO:0046872 metal ion binding
Biological Process
GO:0018344 protein geranylgeranylation
Cellular Component
GO:0005968 Rab-protein geranylgeranyltransferase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3hxc, PDBe:3hxc, PDBj:3hxc
PDBsum3hxc
PubMed19894725
UniProtQ08603|PGTB2_RAT Geranylgeranyl transferase type-2 subunit beta (Gene Name=Rabggtb)

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